Researchers find a protein that appears to protect
against coronary artery disease in older people with surprisingly clear
arteries
Newswise, April 7, 2016– For many people, coronary
artery disease, or CAD—the buildup of plaque in the heart’s arteries—is an
unfortunate part of aging.
By studying the genetic makeup of those who manage
to maintain clear arteries into old age, researchers have identified a possible
genetic basis for the disease, as well as potential new opportunities to
prevent it.
“We believe that our ever-increasing population of
people age 65 and older holds the key to understanding CAD,” said Jonathan
Schisler, Ph.D., assistant professor of pharmacology at McAllister Heart
Institute of the University of North Carolina at Chapel Hill, who led the
research team.
“Our main goal was to try to understand why some
people develop CAD and some people with similar risk factors do not, and we
found that older people give us a great model to understand the natural disease
process.”
Schisler and his colleagues analyzed blood samples
and heart scans from 143 people over age 65 who were referred to UNC Hospitals
for cardiovascular screening.
The analysis revealed that people with clear
arteries had markedly higher levels of a protein called CXCL5, as well as
genetic variants near the CXCL5 gene, compared with people with more plaque.
“CXCL5 looks to be protective against CAD, and the
more CXCL5 you have, the healthier your coronary arteries are,” said Schisler.
“Our findings suggest that there may be a genetic
basis to CAD and that CXCL5 may be of therapeutic interest to combat CAD in
people.”
Schisler will present this research at the American
Society for Investigative Pathology Annual Meeting during Experimental
Biology 2016.
CAD is the most common cause of heart attacks and
the leading cause of death in the United States. Despite increased awareness of
its risk factors and a variety of available treatment options, CAD has remained
a persistent public health challenge.
“Identifying targets that may lead to treatments or
preventative measures for CAD has immense public health value and the potential
to impact many people,” said Schisler.
Previous studies linked the CXCL5 protein with
inflammation, leading some researchers to assume it was harmful.
But recent research in mice suggested the protein
could help limit plaque buildup by changing the composition of fat and
cholesterol deposits in the arteries. This study offers the first evidence that
CXCL5 could play a protective role in people, at least in the context of CAD.
In addition to offering clues about how CAD
develops, the study opens new possibilities for prevention and treatment.
For example, it may be possible to develop a drug
that mimics the effects of CXCL5 or that increases the body’s natural CXCL5
production to help prevent CAD in people at high risk. The protein could even
potentially be leveraged to develop a new, nonsurgical approach to help clear
already-clogged arteries.
One limitation of the study is that because all
participants were referred for a heart scan, the study did not include a group
of healthy controls. Further research is needed to confirm the role of CXCL5 in
CAD and explore drug development opportunities.
Schisler said that for him, although the research is
in its early stages, “it’s a glimmer of hope in a battle worth fighting.”
“I lost both of my grandfathers to cardiovascular
disease, one so early I do not even have any memories of him,” said Schisler.
“This has been a driving force for me to not only understand heart disease, but
also find treatments that allow healthy, longer lives.”
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