Search This Blog

Monday, January 16, 2017

Sunlight Offers Surprise Benefit — It Energizes Infection Fighting T Cells

Sunshine benefit fights infection
Newswise, January 16, 2017-- Sunlight allows us to make vitamin D, credited with healthier living, but a surprise research finding could reveal another powerful benefit of getting some sun. 

Georgetown University Medical Center researchers have found that sunlight, through a mechanism separate than vitamin D production, energizes T cells that play a central role in human immunity.

Their findings, published today in Scientific Reports, suggest how the skin, the body’s largest organ, stays alert to the many microbes that can nest there.

“We all know sunlight provides vitamin D, which is suggested to have an impact on immunity, among other things. But what we found is a completely separate role of sunlight on immunity,” says the study’s senior investigator, Gerard Ahern, PhD, associate professor in the Georgetown’s Department of Pharmacology and Physiology.

“Some of the roles attributed to vitamin D on immunity may be due to this new mechanism.”

They specifically found that low levels of blue light, found in sun rays, makes T cells move faster — marking the first reported human cell responding to sunlight by speeding its pace.

“T cells, whether they are helper or killer, need to move to do their work, which is to get to the site of an infection and orchestrate a response,” Ahern says.

“This study shows that sunlight directly activates key immune cells by increasing their movement.”

Ahern also added that while production of vitamin D required UV light, which can promote skin cancer and melanoma, blue light from the sun, as well as from special lamps, is safer.

And while the human and T cells they studied in the laboratory were not specifically skin T cells — they were isolated from mouse cell culture and from human blood — the skin has a large share of T cells in humans, he says, approximately twice the number circulating in the blood.

“We know that blue light can reach the dermis, the second layer of the skin, and that those T cells can move throughout the body,” he says.

The researchers further decoded how blue light makes T cells move more by tracing the molecular pathway activated by the light.

What drove the motility response in T cells was synthesis of hydrogen peroxide, which then activated a signaling pathway that increases T cell movement.

Hydrogen peroxide is a compound that white blood cells release when they sense an infection in order to kill bacteria and to “call” T cells and other immune cells to mount an immune response.

“We found that sunlight makes hydrogen peroxide in T cells, which makes the cells move. And we know that an immune response also uses hydrogen peroxide to make T cells move to the damage,” Ahern says. “This all fits together.”

Ahern says there is much work to do to understand the impact of these findings, but he suggests that if blue light T cell activation has only beneficial responses, it might make sense to offer patients blue light therapy to boost their immunity.

Study co-authors include lead investigator Thieu X. Phan, PhD, Barbara Jaruga, PhD, Sandeep C. Pingle, PhD, and Bandyopadhyay, PhD, all from the Georgetown University Medical Center’s Department of Pharmacology and Physiology.

The authors report having no personal financial interests related to the study.

The study was supported by a pilot grant from the National Multiple Sclerosis Society. 

1 comment:

  1. I'm here to testify about the great work Dr jatto did for me. I have been suffering from viral disease for the past 11 months and had constant pain, especially in my face, I was feeling bad During the 6th months, I had faith in God that i would be healed someday. This virus started circulating all over my body and i have been taking treatment from my doctor, few weeks ago i came across a testimony of one lady on the internet testifying about a Man called Dr jatto on how he cured her from viral diseases And she gave the email address of this man and advise anybody to contact him for help for any kind of sickness that he would be of help, so I emailed him telling him about my rival virus he told me not to worry that i was going to be cured!! Well i never believed it,, well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me as Dr jatto assured me that i will be cured, after some time i went to my doctor to confirmed if i have be finally healed behold it was TRUE, So friends my advise is if you have such sickness or any other at all you can contact +12564174927 EMAIL drjattosolutionhome@gmail.com or website http://drjattosolutionhome.webs.com
    NOTE THAT THIS GREAT MAN CAN CURE ANY TYPES OF SICKNESS OKAY VIRAL DISEASE
    ROSACEA VIRUS
    MOLLUSCUM
    HIV
    CANCER
    DIABETES
    PLANTAR WART
    URTICARIA
    HERPES
    PENIS ENLARGMENT
    ZIKA VIRUS
    LOW SPWERM COUNT
    WEAK EJACULATION
    INFERTILITY
    AND MANY MORE.........

    ReplyDelete