Do Risk Factors For Breast Cancer Change With A Woman’s Age?

Texas A&M researcher focused on understanding which women are at increased risk of the disease, and when

Newswise, October 24, 2016 — Breast cancer is the most common cancer among women in the United States, with more than 230,000 diagnoses each year. Around 12.4 percent of American women will develop the disease at some point. Given these statistics, understanding and treating the disease is of great public health importance.

“Breast cancer is a serious disease that tends to strike women in the prime of their lives,” said Robin Fuchs-Young, PhD, a professor and breast cancer researcher at the Texas A&M College of Medicine. “Although there are many challenges, we’re making great strides in understanding breast cancer.”

Fuchs-Young’s laboratory is trying to understand why some women get breast cancer and others don’t, and why some women survive and others don’t. “If we can understand what the contributors are, we may be able to identify ways to better treat, and even prevent, this disease,” she said.

“There are many of us asking these questions, all over the country and all over the world, and the answers are complex, with multiple factors involved.”

Therefore, Fuchs-Young’s lab studies multiple contributors to breast cancer, especially those that may change the nature of the disease.

Some of her earlier work has shown that risk of breast cancer is affected by the levels of a small peptide hormone called insulin-like growth factor 1.

She is studying the possibility that higher levels of this growth factor early in life may be important in the development of early onset breast cancer, which Fuchs-Young says can be very different from breast cancer that occurs later in a woman’s life.

“In some ways, breast cancer can be broken down into cancer that develops early in life—what we call early onset breast cancer—and late, post-menopausal breast cancer,” she said.

The former tends to be more aggressive and harder to treat, while the latter tends to be more treatable with the drugs available now.

Breast cancer that occurs later in life usually has receptors for estrogen and progesterone and tends to be more treatable, at least in the short term.

The tumors arising in post-menopausal women usually respond well to available medications that either lower the amount of estrogen in the body or block the hormones that can cause cancer cells to grow.

On the other hand, early onset cancers tend to act differently: they are more aggressive, often grow faster and do not respond to drugs that block steroid hormones.

Early and late onset breast cancer may have different contributing risk factors as well. “There’s no single thing that causes cancer,” Fuchs-Young said.

“It’s always this combination of genetic variations, mutations—which are not the same thing—and environmental exposures, and other things we call ‘modifiers,’ like diet.”

“One of the challenges is understanding how the various contributors—like diet, genetics, environmental exposures and others—interact.”

Adding to the complexity is that the effect of external influences on breast cancer susceptibility may depend on when the exposures occur.

This is a concept called “windows of susceptibility.”

“Our working hypothesis is that there is a connection between early onset breast cancer and early exposures to certain risk factors, one of which may be diet,” Fuchs-Young said.

This is what her laboratory is investigating, using various types of models to try to understand causes and possibly identify ways to reduce the risk, or even completely prevent breast cancer.

“Determining how breast cancer develops and how to treat it is a fascinating scientific question and an important challenge,” Fuchs-Young added. “We think we’re making progress.”

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About Texas A&M Health Science Center
Texas A&M Health Science Center is Transforming Health through innovative research, education and service in dentistry, medicine, nursing, pharmacy, public health and medical sciences. As an independent state agency and academic unit of Texas A&M University, the health science center serves the state through campuses in Bryan-College Station, Dallas, Temple, Houston, Round Rock, Kingsville, Corpus Christi and McAllen. Learn more at vitalrecord.tamhsc.edu or follow @TAMHSC on Twitter.

Find the Silver Linings in Life Bestselling author, nurse and breast cancer survivor shares advice for healthy living

October 1, 2015, (Family Features)-- Every year, approximately 250,000 people are diagnosed with breast cancer. As a vegan-eating, marathon-running, mother in her 30s with no family history of breast cancer, Hollye Jacobs was unexpectedly diagnosed with the disease.

Now, the nurse turned New York Times bestselling author of “The Silver Lining: A Supportive and Insightful Guide to Breast Cancer” has partnered with Allstate to help everyone impacted by cancer receive a free guide with practical tips, important information and inspiration to inform and support people from diagnosis, through treatment and recovery, and into life after cancer.

“I am honored to partner with Allstate to empower women with knowledge to take control of their health and encourage each other along the way,” said Jacobs. “I hope we can all be there for each other and find the silver linings in life.”

As a follow-up to her successful book, Jacobs offers this inspiring advice on how to find the silver lining and feel your best in any situation:

·        Dress the part: Dress to feel your best no matter where your day takes you, from school to work to chemotherapy. Invest in pieces that make you feel comfortable and confident. During her chemotherapy experience, Jacobs found that cotton scarves were the easiest to tie and most effective at staying comfortably on her head when out and about.

·        Exercise: Pace yourself and set reasonable goals to take control of a healthy lifestyle. Begin slowly but consistently to establish a positive habit on which you can build; even a slow stroll can be transformative for your health.

·        Healthy eating: Like exercise, good nutrition helps offset exhaustion that comes with the weight of daily stresses and fatigue. A balanced and healthy diet doesn’t have to be expensive. Incorporate nutrient-dense foods like avocados and nuts, and drink plenty of water. Whenever possible, avoid alcohol, sugar and processed foods.

·        Encourage each other: Jacobs’ biggest life lesson from her experience with cancer was that asking for help is a sign of strength, not weakness. If you think that you could benefit from professional or spiritual support, pursue it. Celebrate positive thinking and remember that everyone reacts to life’s unexpected struggles and pain differently. Be kind and patient with others and, most importantly, yourself.

·        Express yourself: For Jacobs, writing was cathartic. Her book evolved from her blog, www.TheSilverPen.com, which unexpectedly reached audiences far beyond her circle of friends and family. She encourages people to write down at least three silver linings each day, from noticing the color of a flower to petting an animal.

·        Educate yourself: Be an active participant in your health by learning from trusted sources and resisting the urge to blindly search online for information. When learning anything new, be patient, open, flexible and assertive to find what works best and most comfortably for your routine.

The free Silver Lining Companion Guide is available for download or for pick up at participating distribution centers and select Allstate agencies nationwide. Download or find the nearest participating distribution center at www.Allstate.com/SilverLining.

Photo courtesy of Getty Images