These
findings have been reported by a team from Roswell Park Cancer Institute and
Everon Biosciences in the journal Aging.
“The majority of aging theories
agree that chronic inflammation associated with secretions by senescent, or
aging, cells are the underlying cause of frailty and of multiple age-related
diseases, including cancer,” says senior author Andrei Gudkov, PhD, DSci,
Senior Vice President for Basic Science at Roswell Park.
“Our study has redefined a subset of
these cells as belonging to the category of macrophages. This finding requires
a re-interpretation of the mechanisms underlying these cellular targets and a
reconsideration of their potential for anti-aging treatments.”
Scientists have named the subtype
“senescence-associated macrophages,” or SAMS.
“Our research allowed us to redefine
the nature of cells that are sources of poisonous inflammation associated with
aging. These cells appear to be not senescent cells, but are actually part of
our natural immune system. This finding allows us to identify targets as well
as agents that can eradicate senescence-associated macrophages, with the
ultimate goal of finding new ways to treat cancer and other age-related diseases,”
adds Dr. Gudkov.
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